Fourier photoacoustic microscope improved resolution on single-pixel imaging

Abstract

A new single-pixel Fourier photoacoustic microscopy (PAM), to the best of our knowledge, is proposed to improve the resolution and region of interest (ROI) of an acquired image. In the previous structure of single-pixel Fourier PAM, called spatially invariant resolution PAM (SIR-PAM), the lateral resolution and ROI are limited by the digital micromirror device (DMD) pixel size and the number of pixels. This limitation is overcome here through illuminating fixed angle interfering plane waves, changing the fringe frequency via varying the frequency of the laser source. Given that the fringe sinusoidal patterns here can be produced by two mirrors, the DMD usage can be omitted. In this way, the fringe frequency can be changed in a wider spectrum, making it possible to capture a wider spectral bandwidth and thus a higher-resolution image. Also, the removal of the ROI limitation results in a high-resolution frequency-swept PAM structure. Monte Carlo simulations show 1.7 times improvement in lateral resolution compared to SIR-PAM based on the point-spread function and full-width-at-half-maximum.