Affiliation:
1. South China University of Technology
2. Guangdong Academy of Medical Sciences
Abstract
Just-in-time burn severity assessment plays a vital role in burn treatment and care. However, it is still difficult to quantitatively and promptly evaluate burn severity by existing medical imaging methods via initial burn depth measurement since burn wounds are usually dynamically developed. As an elastic skeleton of skin, the degree of conformational changes of collagen fibers caused by overheating can reflect the burn severity in a timelier manner. Herein, the polarized photoacoustic technique (PPAT) for just-in-time quantitative evaluation of burn severity via collagen fiber anisotropy assessment is proposed. First, phantom experiments demonstrate the ability of PPAT for deep imaging in a transport mean free path and accurately quantify changes in microstructural order by thermal damage. Then, the Pearson correlation coefficient of the PPAT in assessing burn severity is shown to be up to 0.95, validated by burn skin samples. The PPAT provides a just-in-time quantitative strategy for burn severity evaluation.
Funder
National Natural Science Foundation of China
Science and Technology Planning Project of Guangdong Province
Guangzhou Science and Technology Plan Project
Science and Technology Program of Guangzhou
Basic and Applied Basic Research Foundation of Guangdong Province
Subject
Atomic and Molecular Physics, and Optics,Electronic, Optical and Magnetic Materials
Cited by
9 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献