Author:
Lewis Alistair,Hobson Lucas J.,Lin Yuxi,S.Wulwick Karli,Davis Anthony M.,Sueishi Takayuki,Morton Shannon L.,Morton Sarah,Stumpf Kate,Starr Jonathan P.,Gaudio Hunter,Fagan Nicholas,Kilbaugh Todd J.,Forti Rodrigo M.,Ko Tiffany S.,Yodh Arjun G.,McManus Meagan J.,Baker Wesley B.
Abstract
We compared non-invasive diffuse optical measurements of cerebral oxygen extraction fraction and oxidized cytochrome-c-oxidase against invasive microdialysis measurements of cerebral lactate-to-pyruvate ratio in a swine model of acute mitochondrial complex I dysfunction.