Time-gated single-pixel imaging of Cherenkov emission from a medical linear accelerator

Author:

Jia MengyuORCID,Wei Zhaoqi,Gao Feng1,Jiang Mingfeng2,Wang Wei345,Yuan Zhiyong345,Pogue Brian W.67

Affiliation:

1. Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments

2. Zhejiang Sci-Tech University

3. Tianjin Medical University Cancer Institute & Hospital

4. Key Laboratory of Cancer Prevention and Therapy

5. National Clinical Research Center for Cancer

6. University of Wisconsin-Madison

7. Thayer School of Engineering, Dartmouth College

Abstract

Cherenkov imaging is an ideal tool for real-time in vivo verification of a radiation therapy dose. Given that radiation is pulsed from a medical linear accelerator (LINAC) together with weak Cherenkov emissions, time-gated high-sensitivity imaging is required for robust measurements. Instead of using an expensive camera system with limited efficiency of detection in each pixel, a single-pixel imaging (SPI) approach that maintains promising sensitivity over the entire spectral band could be used to provide a low-cost and viable alternative. A prototype SPI system was developed and demonstrated here in Cherenkov imaging of LINAC dose delivery to a water tank. Validation experiments were performed using four regular fields and an intensity-modulated radiotherapy (IMRT) delivery plan. The Cherenkov image-based projection percent depth dose curves (pPDDs) were compared to pPDDs simulated by the treatment planning system (TPS), with an overall average error of 0.48, 0.42, 0.65, and 1.08% for the 3, 5, 7, and 9 cm square beams, respectively. The composite image of the IMRT plan achieved a 85.9% pass rate using 3%/3 mm gamma index criteria, in comparing Cherenkov intensity and TPS dose. This study validates the feasibility of applying SPI to the Cherenkov imaging of radiotherapy dose for the first time to our knowledge.

Funder

National Natural Science Foundation of China

Key Research and Development Program of Zhejiang Province

National Key Research and Development Program of China

Publisher

Optica Publishing Group

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