Numerical approach to design the graphene-based multilayered surface plasmon resonance biosensor for the rapid detection of the novel coronavirus

Abstract

In this article, a graphene-based multilayered surface plasmon resonance (SPR) biosensor of (BK7/WS2/Au/BaTiO3/Graphene) is proposed for the rapid detection of the novel coronavirus (COVID-19). The proposed SPR biosensor is designed based on the angular interrogation attenuated total reflection (ATR) method for rapid detection of the COVID-19 virus. The sensor’s surface plasmon polaritons (SPPs) and the sensing region refractive index (RI) are changed, owing to the interaction of various concentrated ligand-analytes. The specific ligand is mechanized with the proposed sensor surface and the target analyte that has flowed onto the sensing surface. The proposed sensor is capable of detecting the COVID-19 virus rapidly in two different ligand-analytes environments, such as: (i) the virus spike receptor-binding domain (RBD) as an analyte and monoclonal antibodies (mAbs) as a probe ligand, and (ii) the monoclonal antibodies (IgG or IgM) as an analyte and the virus spike RBD as a probe ligand. Due to the binding of the target ligand-analytes, the concentration level of the sensing region is incremented. As the increment in the concentration level, the RI of the sensing medium increases, therefore the change in RI causes the shift in the SPR angle resulting in the output reflectance intensity. The performance of the multilayered SPR sensor is analyzed numerically using the finite element method (FEM) method. Numerically, the proposed sensor provides the maximum angular shift sensitivity at 230.77 deg/refractive index unit (RIU), detection accuracy (DA) at 0.161 deg−1, and the figure of merits (FOM) is at 37.22 RIU−1. In addition, with each additional graphene layer number (L), the proposed sensor exhibits the angular shift sensitivity increment (1 + 0.7L) times. The novelty of the proposed multilayer (BK7/WS2/Au/BaTiO3/Graphene) sensor is highly angular sensitivity, and capable of detecting the COVID-19 virus rapidly without a false-positive report.