Highly sensitive ZnO/Ag/BaTiO3/MoS2 hybrid structure-based surface plasmon biosensor for the detection of mycobacterium tuberculosis bacteria

Abstract

This study presents a novel biosensor utilizing surface plasmon resonance (SPR) technology, comprising og zinc oxide (ZnO), silver (Ag), barium titanate (BaTiO3), and molybdenum disulfide (MoS2). The detection of mycobacterium tuberculosis bacteria was accomplished through the utilization of the hybrid structure. The transfer matrix method (TMM) and finite element method are employed to analyze the suggested surface plasmon resonance (SPR) structure. A comparative analysis has been conducted to evaluate the angular sensitivity between normal blood samples (NBS) and cells affected by tuberculosis (TB). The optimization of the performance of the surface plasmon resonance (SPR) structure involves adjusting the thickness of ZnO, Ag and BaTiO3 layer. The accurate measurement of the full width at half maximum (FWHM), detection accuracy (DA), quality factor and figure of merits (FOM) has also been conducted. The optimal angular sensitivity has been determined to be 10 nm for ZnO, 40 nm for Ag, 1.5 nm for BaTiO3, and one layer of MoS2 with a sensitivity of 525 deg./RIU. Additionally, this study compared the effects on sensitivity of two dimensional materials graphene, WS2 and MoS2. In contrast to the currently available biosensor utilizing surface plasmon resonance (SPR), the suggested structure exhibits higher angular sensitivity. Due to its improved sensitivity, the biosensor under consideration exhibits potential for detecting a wide range of biological analytes and organic compounds.