Requirement of β subunit for the reduced voltage-gated Na<sup>+</sup> current of a Brugada syndrome patient having novel double missense mutation (p.A385T/R504T) of <i>SCN5A</i>-Reference-Cited by-同舟云学术

Requirement of β subunit for the reduced voltage-gated Na⁺ current of a Brugada syndrome patient having novel double missense mutation (p.A385T/R504T) of SCN5A

Published:2024-07-01 Issue:4 Volume:28 Page:313-322
ISSN:1226-4512
Container-title:The Korean Journal of Physiology & Pharmacology
language:en
Short-container-title:Korean J Physiol Pharmacol

Author:

Park Na Kyeong¹,Choi Seong Woo²³,Park Soon-Jung⁴,Woo JooHan²³,Kim Hyun Jong²³,Kim Woo Kyung³⁵,Moon Sung-Hwan⁶,Park Hun-Jun⁷,Kim Sung Joon¹⁸

Affiliation:

1. Department of Physiology, Seoul National University College of Medicine, Seoul 03080, Korea

2. Department of Physiology, Dongguk University College of Medicine, Gyeongju 38066, Korea

3. Channelopathy Research Center (CRC), Dongguk University College of Medicine, Goyang 10326, Korea

4. R&D Center, Biosolvix Co. Ltd, Seoul 08502, Korea

5. Department of Internal Medicine Graduate School of Medicine, Dongguk University, Goyang 10326, Korea

6. Department of Animal Science and Technology, Chung-Ang University, Anseong 17546, Korea

7. Division of Cardiology, Department of Internal Medicine, Uijeonbu St.Mary’s Hospital, The Catholic University of Korea, Seoul 11765, Korea

8. Department of Physiology & Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul 03080, Korea

Funder

National Research Foundation of Korea

Publisher

The Korean Physiological Society and The Korean Society of Pharmacology

Link

https://pdf.medrang.co.kr/KJPP2/2024/028/KJPP028-04-03.pdf

Reference21 articles.

1. Sudden Cardiac Death and Genetic Ion Channelopathies

2. Biology of cardiac sodium channel Nav1.5 expression

3. Clinical Spectrum of SCN5A Mutations

4. Carmeliet E. Congenital LQT syndrome from gene to torsade de pointes. Korean J Physiol Pharmacol. 2002;6:1-8.

5. Long QT syndrome, Brugada syndrome, and conduction system disease are linked to a single sodium channel mutation