A Study on the Anti-Inflammatory Effect and Improvement of Dyslipidemia on <italic>Hyangsapyeongwi-san</italic>

Abstract

Objectives: This study aims to investigate the anti-inflammatory effect and improvement of dyslipidemia on <i>Hyangsapyeongwi-san</i>.Methods: In this study, HUVEC cells were cultured and treated with <i>Hyangsapyeongwi-san</i> to measure intracellular KLF2, eNOS, MCP-1, ICAM-1, and VCAM-1 gene expression levels related to anti-inflammation. The weight of experimental animals administered with <i>Hyangsapyeongwi-san</i> was measured, blood samples were biochemically analyzed, and liver tissues were reviewed to research histological changes.Results: Gene expression levels in the cells treated with <i>Hyangsapyeongwi-san</i> generally showed a meaningful anti-inflammatory effect. The body weight of the experimental animals decreased, and total cholesterol, triglyceride, and LDL-cholesterol in the blood generally declined while HDL-cholesterol tended to increase. Fat accumulation between hepatocytes was also reduced after the administration of <i>Hyangsapyeongwi-san</i>.Conclusions: This study confirmed that <i>Hyangsapyeongwi-san</i> has the effect of suppressing vascular inflammatory responses through the regulation of genes involved in the vascular inflammatory process and improving dyslipidemia through the reduction of blood lipids and weight loss.