The fluids as starting infusion therapy in the early postoperative period in children: solution with succinate or malate. A prospective, randomized study

Abstract

The problem of choosing an infusion solution, especially in starting therapy, for various critical conditions, remains debatable, especially in children with specifics of water-electrolyte metabolism, which determines their tendency to imbalance of water and electrolytes. Objectives. Comparative evaluation of the succinate-containing solution and the malate-containing solution as a starting infusion therapy in the early postoperative period in children. Materials and methods. A randomized prospective study in 40 patients with an ASA II-III score who underwent an operation. In the first group “R” 20 children receive succinate-containing solution and in the second group “S” 20 children receive malate-containing solution. At the study stages inter-and intra- group differences were estimated by the dynamics of the water-electrolyte and acid-base conditions, phase angle values - the calculated integral indicator of the state of the membranes of cell structures, and basal metabolism. Results. No significant differences between groups at all stages of the study were obtained. However, in group “S” there was a dynamic, statistically significant by 180 minutes after the start of fluid administration, a decrease in the phase angle by 4.1 %, despite the fact that in group “R” the deviations were not significant. Conclusion. There were no statistically significant differences between the solutions used as starting infusion therapy drugs in the early postoperative period in the indicated modes, and they can be used equally well. However, the noted statistically significant changes in the phase angle in the group with malate-containing solution indicated a tendency to it is negative effect on the state of cell structures, which, apparently, should be taken into account with more significant volumes and duration of fluid administration.