Affiliation:
1. V.V. Veresaev Municipal Clinical Hospital
2. Russian Research Institute of Hematology and Transfusiology
Abstract
Acute lymphoblastic leukemia is one of the groups of most challenging malignant neoplasms of hematopoietic tissue. Despite the success in achieving remission induction in primary patients, later, most of them develop disease relapses. Overall and disease-free survivals have to be improved, which cannot be achieved solely with chemotherapy intensification. The new target drugs and cell technologies improve the treatment options for the resistant forms and relapses of acute lymphoblastic leukemia. The effective use of new drugs presupposes their timely assignment which can be ensured by their availability in routine clinical practice. The provided case report describes the successful use of bispecific antibody blinatumomab for treating an early relapse of acute lymphoblastic leukemia in the clinical practice within the municipal healthcare system.
Publisher
Practical Medicine Publishing House
Reference22 articles.
1. Pui CH, Robison LL, Look AT. Acute lymphoblastic leukaemia. Lancet. 2008;371(9617):1030-43. doi: 10.1016/s0140-6736(08)60457-2.
2. Vos T, Allen C, Arora M, et al. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388(10053):1545-602. doi: 10.1016/S0140-6736(16)31678-6.
3. Савченко В.Г., Паровичникова Е.Н., Афанасьев Б.В. и др. Клинические рекомендации по диагностике и лечению острых лимфобластных лейкозов взрослых 2018. (электронный ресурс) Доступно по: https://npngo.ru/uploads/ media_document/293/556718e9-0ff5-46f3-bff8-bd592c83b992.pdf. Ссылка активна на 22.09.2020 г.
4. Kantarjian HM, Walters RS, Keating MJ, et al. Results of the vincristine, doxorubicin, and dexamethasone regimen in adults with standard- and high-risk acute lymphocytic leukemia. J Clin Oncol. 1990;8(6):994-1004. doi: 10.1200/jco.1990.8.6.994.
5. Паровичникова Е.Н., Соколов А.Н., Троицкая В.В. и др. Острые Ph-негативные лимфобластные лейкозы взрослых: факторы риска при использовании протокола ОЛЛ-2009. Терапевтический архив. 2016;88(7):15-24. doi: 10.17116/terarkh201688715-24.
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