Use of an electrophysiological technique for stepwise detection of trace agonist constituents of Hochuekkito in <i>Xenopus</i> oocytes injected with serotonin 2C receptor mRNA-Reference-Cited by-同舟云学术

Use of an electrophysiological technique for stepwise detection of trace agonist constituents of Hochuekkito in Xenopus oocytes injected with serotonin 2C receptor mRNA

Published:2021-06-30 Issue:3 Volume:15 Page:143-149
ISSN:1881-7831
Container-title:Drug Discoveries & Therapeutics
language:en
Short-container-title:DD&T

Author:

Tohda Michihisa¹,Zhao Qingfeng²,Kobayashi Naofumi³,Kazuma Kohei⁴

Affiliation:

1. Laboratory of Consilienceology for Wakan-yaku, Section of Neuromedical Science, Institute of Natural Medicine, University of Toyama, Toyama, Japan.

2. Field of Consilienceology for Wakan-yaku, Major of Biological Information System Course, Graduate School of Innovative Life Science, University of Toyama, Toyama, Japan.

3. Division of Medicinal Pharmacology, Institute of Natural Medicine, University of Toyama, Toyama, Japan.

4. Global Center for Natural Resources Sciences, Graduate Schools of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan.

Publisher

International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA)

Subject

Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics,General Medicine

Link

https://www.jstage.jst.go.jp/article/ddt/15/3/15_2021.01037/_pdf

Reference16 articles.

1. 1. Tohda M, Watanabe H. The Wakan-yaku universe: A useful authorized traditional concept for developing novel therapeutic categories and medicinal drugs. Biol Pharm Bull. 2018; 41:1627-1631.

2. 2. Tohda M, Takasu T, Nomura Y. Effects of antidepressants on serotonin-evoked current in Xenopus oocytes injected with rat brain mRNA. Eur J Pharmacol. 1989; 166:57-63.

3. 3. Tohda M, Mingmalairak S. Evidence of antidepressive effects of a Wakan-yaku, Hochuekkito, in depression model mice with learned-helplessness behavior. Evid Based Complement Alternat Med. 2013; 319073.

4. 4. Tohda M, Abdel-Fattah AFM, Nakamura S, Watanabe H. Effects of Hochu-ekki-to (Bu-Zhong-Yi-Qi-Tang), a Kampo medicine, on serotonin 2C subtype receptor-evoked current response and the receptor mRNA expression. J Tradit Med. 2000; 17:34-40.

5. 5. Tohda M, Hang PT, Kobayashi N, Matsumoto K. Serotonin 2C receptor (5-HT2CR) mRNA editing-induced down-regulation of 5-HT2CR function in Xenopus oocytes: The significance of site C editing. J Pharmacol Sci. 2010; 113:362-367.