Both triazolyl ester of ketorolac (15K) and YM155 inhibit the embryonic angiogenesis <i>in ovo</i> (fertilized eggs) <i>via</i> their common PAK1-survivin/VEGF signaling pathway-Reference-Cited by-同舟云学术

Both triazolyl ester of ketorolac (15K) and YM155 inhibit the embryonic angiogenesis in ovo (fertilized eggs) via their common PAK1-survivin/VEGF signaling pathway

Published:2017 Issue:6 Volume:11 Page:300-306
ISSN:1881-7831
Container-title:Drug Discoveries & Therapeutics
language:en
Short-container-title:DD&T

Author:

Ahn Mok-Ryeon¹,Bae Ji-Yeon¹,Jeong Da-Hye¹,Takahashi Hideaki²,Uto Yoshihiro²,Maruta Hiroshi³

Affiliation:

1. Department of Food Science and Nutrition, Dong-A University

2. Tokushima University

3. PAK Research Center

Publisher

International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA)

Subject

Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics,General Medicine

Link

https://www.jstage.jst.go.jp/article/ddt/11/6/11_2017.01058/_pdf

Reference21 articles.

1. 1. Maruta H. Herbal therapeutics that block the oncogenic kinase PAK1: A practical approach towards PAK1-dependent diseases and longevity. Phytother Res. 2014; 28:656-672.

2. 2. Yanase S, Luo Y, Maruta H. PAK1-deficiency/down-regulation reduces brood size, activates HSP16.2 gene and extends lifespan in Caenorhabditis elegans. Drug Discov Ther. 2013; 7:29-35.

3. 3. Be-Tu PT, Nguyen BC, Tawata S, Yun CY, Kim EG, Maruta H. The serum/PDGF-dependent "melanogenic" role of the minute level of the oncogenic kinase PAK1 in melanoma cells proven by the highly sensitive kinase assay. Drug Discov Ther. 2017; 10:314-322.

4. 4. Kolb HC, Finn MG, Sharpless KB. Click chemistry: Diverse chemical function from a few good reactions. Angew Chem Int Ed Engl. 2001; 40:2004-2021.

5. 5. Nguyen BC, Takahashi H, Uto Y, Shahinozzaman MD, Tawata S, Maruta H. 1,2,3-Triazolyl ester of ketorolac: A "Click Chemistry"-based highly potent PAK1-blocking cancer-killer. Eur J Med Chem. 2017; 126:270-276.

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