Inhaled ciclesonide does not affect production of antibodies or elimination of virus in patients with COVID-19: Subanalysis of a multicenter, open-label randomized trial-Reference-Cited by-同舟云学术

Inhaled ciclesonide does not affect production of antibodies or elimination of virus in patients with COVID-19: Subanalysis of a multicenter, open-label randomized trial

Published:2023-10-31 Issue:5 Volume:17 Page:304-311
ISSN:1881-7831
Container-title:Drug Discoveries & Therapeutics
language:en
Short-container-title:DD&T

Author:

Suzuki Manabu¹,Matsunaga Akihiro²,Miyoshi-Akiyama Tohru³,Terada-Hirashima Junko¹,Sadamasu Kenji⁴,Nagashima Mami⁴,Takasaki Jin¹,Izumi Shinyu¹,Hojo Masayuki¹,Ishizaka Yukihito²,Sugiyama Haruhito¹

Affiliation:

1. Department of Respiratory Medicine, National Center for Global Health and Medicine, Tokyo, Japan.

2. Department of Intractable Diseases, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.

3. Pathogenic Microbe Laboratory, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.

4. Tokyo Metropolitan Institute of Public Health, Tokyo, Japan.

Publisher

International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA)

Subject

Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics,General Medicine

Link

https://www.jstage.jst.go.jp/article/ddt/17/5/17_2023.01078/_pdf

Reference19 articles.

1. 1. Williamson EJ, Walker AJ, Bhaskaran K, et al. Factors associated with COVID-19-related death using OpenSAFELY. Nature. 2020; 584:430-436.

2. 2. Horby P, Lim WS, Emberson JR, et al. Dexamethasone in hospitalized patients with Covid-19. N Engl J Med. 2021; 384:693-704.

3. 3. Indari O, Jakhmola S, Manivannan E, Jha HC. An update on antiviral therapy against SARS-CoV-2: How far have we come? Front Pharmacol. 2021; 12:632677.

4. 4. Matsuyama S, Kawase M, Nao N, Shirato K, Ujike M, Kamitani W, Shimojima M, Fukushi S. The inhaled steroid ciclesonide blocks SARS-CoV-2 RNA replication by targeting the viral replication-transcription complex in cultured cells. J Virol. 2020; 95:e01648-20.

5. 5. Iwabuchi K, Yoshie K, Kurakami Y, Takahashi K, Kato Y, Morishima T. Therapeutic potential of ciclesonide inhalation for COVID-19 pneumonia: report of three cases. J Infect Chemother. 2020; 26:625-632.

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