Rapamycin <i>vs</i> TORin-1 or Gleevec <i>vs</i> Nilotinib: Simple chemical evolution that converts PAK1-blockers to TOR-blockers or <i>vice versa</i>?
Author:
Affiliation:
1. PAK Research Center, Melbourne, Australia.
2. Melbourne University Hospital (Austin Health), Melbourne, Australia.
Publisher
International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA)
Link
https://www.jstage.jst.go.jp/article/ddt/18/2/18_2023.01097/_pdf
Reference55 articles.
1. 1. Chiu MI, Katz H, Berlin V. RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex. Proc Natl Acad Sci U S A. 1994; 91:12574-12578.
2. 2. Stan R, McLaughlin MM, Cafferkey R, Johnson RK, Rosenberg M, Livi GP. Interaction between FKBP12-rapamycin and TOR involves a conserved serine residue. J Biol Chem. 1994; 269:32027-32030.
3. 3. Brown EJ, Albers MW, Shin TB, K Ichikawa, Keith CT, Lane WS, Schreiber SL. A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature. 1994; 369:756-758.
4. 4. Sabatini DM, Erdjument-Bromage H, Lui M, Tempst P, Snyder SH. RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell. 1994; 78:35-43.
5. 5. Manser E, Leung T, Salihuddin H, Zhao ZS, Lim L. A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature. 1994; 367:40-46.
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