1,2,3-Triazolyl ester of ketorolac (15K), a potent PAK1 blocker, inhibits both growth and metastasis of orthotopic human pancreatic cancer xenografts in mice-Reference-Cited by-同舟云学术

1,2,3-Triazolyl ester of ketorolac (15K), a potent PAK1 blocker, inhibits both growth and metastasis of orthotopic human pancreatic cancer xenografts in mice

Published:2019-10-31 Issue:5 Volume:13 Page:248-255
ISSN:1881-7831
Container-title:Drug Discoveries & Therapeutics
language:en
Short-container-title:DD&T

Author:

Hennig Rene¹,Albawardi Alia²,Almarzooqi Saeeda²,Haneefa Shoja³,Imbaraj Edward³,Zaaba Nur Elena³,Nemmar Abderrahim³,Subramanya Sandeep³,Maruta Hiroshi⁴,Adrian Thomas E.³⁵

Affiliation:

1. Department of General and Visceral Surgery, Freudenstadt University Hospital, Freudenstadt, Germany.

2. Department of Pathology, United Arab Emirates University, Al Ain, UAE.

3. Department of Physiology, United Arab Emirates University, Al Ain, UAE.

4. PAK Research Center, Melbourne, Australia.

5. Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, UAE.

Publisher

International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA)

Subject

Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics,General Medicine

Link

https://www.jstage.jst.go.jp/article/ddt/13/5/13_2019.01068/_pdf

Reference24 articles.

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2. 2. Jagadeeshan S, Venkatraman G, Rayala SK. Targeting p21 activated kinase 1 (Pak1) to PAKup pancreatic cancer. Expert Opin Ther Targets. 2016; 20:1283-1285.

3. 3. Hirokawa Y, Levitzki A, Lessene G, Baell J, Xiao Y, Zhu H, Maruta H. Signal therapy of human pancreatic cancer and NF1-deficient breast cancer xenograft in mice by a combination of PP1 and GL-2003, anti-PAK1 drugs (Tyr-kinase inhibitors). Cancer Lett. 2007; 245:242-251.

4. 4. Nguyen BCQ, Takahashi H, Uto Y, Shahinozzaman MD, Tawata S, Maruta H. 1,2,3-Triazolyl ester of Ketorolac: A "click chemistry"-based highly potent PAK1-blocking cancer-killer. Eur J Med Chem. 2017; 126:270-276.

5. 5. Vit JP, Ohara PT, Tien DA, Fike JR, Eikmeier L, Beitz A, Wilcox GL, Jasmin L. The analgesic effect of low dose focal irradiation in a mouse model of bone cancer is associated with spinal changes in neuro-mediators of nociception. Pain. 2006; 120:188-201.

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