Thrombin cleaves recombinant soluble thrombomodulin into a lectin-like domain fragment and a fragment with protein C-activating cofactor activity-Reference-Cited by-同舟云学术

Thrombin cleaves recombinant soluble thrombomodulin into a lectin-like domain fragment and a fragment with protein C-activating cofactor activity

Published:2022-12-25 Issue:6 Volume:16 Page:444-446
ISSN:1881-7815
Container-title:BioScience Trends
language:en
Short-container-title:BST

Author:

Yokoyama Hirota¹,Tateishi Koichiro¹,Baba Yurie¹,Kobayashi Akina¹,Hashimoto Manami¹,Fukuda Shion¹,Yamao Hinano¹,Maruyama Taiga¹,Nakata Munehiro¹,Matsushita Misao¹

Affiliation:

1. Department of Applied Biochemistry, Tokai University, Hiratsuka, Japan.

Publisher

International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA)

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine,Health (social science)

Link

https://www.jstage.jst.go.jp/article/bst/16/6/16_2022.01472/_pdf

Reference22 articles.

1. 1. Okamoto T, Tanigami H, Suzuki K, Shimaoka M. Thrombomodulin: A bifunctional modulator of inflammation and coagulation in sepsis. Crit Care Res Pract. 2012; 2012:614545

2. 2. Shi CS, Shi GY, Hsiao HM, Kao YC, Kuo KL, Ma CY, Kuo CH, Chang BI, Chang CF, Lin CH, Wong CH, Wu HL. Lectin-like domain of thrombomodulin binds to its specific ligand Lewis Y antigen and neutralizes lipopolysaccharide-induced inflammatory response. Blood. 2008; 112:3661-3670.

3. 3. Abeyama K, Stern DM, Ito Y, Kawahara K, Yoshimoto Y, Tanaka M, Uchimura T, Ida N, Yamazaki Y, Yamada S, Yamamoto Y, Yamamoto H, Iino S, Taniguchi N, Maruyama I. The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism. J Clin Invest. 2005; 115:1267-1274.

4. 4. ItoT, Kawahara K, Okamoto K, Yamada S, Yasuda M, Imaizumi H, Nawa Y, Meng X, Shrestha B, Hashiguchi T, Maruyama I. Proteolytic cleavage of high mobility group box 1 protein by thrombin-thrombomodulin complexes. Arterioscler Thromb Vasc Biol. 2008; 28:1825-1830.

5. 5. Lin WL, Chang CF, Shi CS, Shi GY, Wu HL. Recombinant lectin-like domain of thrombomodulin suppresses vascular inflammation by reducing leukocyte recruitment via interacting with Lewis Y on endothelial cells. Arterioscler Thromb Vasc Biol. 2013; 33:2366-2373.

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