Abstract
BackgroundRegistry-based studies of nephrotic syndrome (NS) may only include a subset of patients with biochemical features of NS. To address this, we compared patients with laboratory-recorded nephrotic proteinuria and hypoalbuminemia to patients with hospital-recorded NS.MethodsWe identified adult patients with first-time hospital-recorded NS (inpatients, outpatients, or emergency-room visitors) in the Danish National Patient Registry and compared them with adults with first-time recorded nephrotic proteinuria and hypoalbuminemia in Danish laboratory databases during 2004–2018, defining the date of admission or laboratory findings as the index date. We characterized these cohorts by demographics, comorbidity, medication use, and laboratory and histopathologic findings.ResultsWe identified 1139 patients with hospital-recorded NS and 5268 patients with nephrotic proteinuria and hypoalbuminemia; of these, 760 patients were identified in both cohorts. Within 1 year of the first record of nephrotic proteinuria and hypoalbuminemia, 18% had recorded hospital diagnoses indicating the presence of NS, and 87% had diagnoses reflecting any kind of nephropathy. Among patients identified with nephrotic proteinuria and hypoalbuminemia, their most recent eGFR was substantially lower (median of 35 versus 61 ml/min per 1.73 m2), fewer underwent kidney biopsies around the index date (34% versus 61%), and the prevalence of thromboembolic disease (25% versus 17%) and diabetes (39% versus 18%) was higher when compared with patients with hospital-recorded NS.ConclusionsPatients with nephrotic proteinuria and hypoalbuminemia are five-fold more common than patients with hospital-recorded NS, and they have a lower eGFR and more comorbidities. Selective and incomplete recording of NS may be an important issue when designing and interpreting studies of risks and prognosis of NS.
Funder
Det Frie Forskningsfond
Nyreforeningen
Dansk Nefrologisk Selskab
Oticon Fonden
Familien Hede Nielsens Fond
Aarhus Universitet
Publisher
American Society of Nephrology (ASN)
Reference28 articles.
1. Nephrotic syndrome in adults
2. Yu ASL , Skorecki K , Marsden PA , Chertow GM , Taal MW : Brenner & Rector’s The kidney, 10th Ed., Amsterdam, Elsevier, 2015
3. Nephrotic syndrome in the elderly;Cameron;Semin Nephrol,1996
4. Association of exposure to fine-particulate air pollution and acidic gases with incidence of nephrotic syndrome;Lin;Int J Environ Res Public Health,2018
5. Kidney disease and risk of venous thromboembolism: a nationwide population-based case-control study
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