Tissue Inhibitor Metalloproteinase-2 and Insulin-Like Growth Factor Binding Protein-7 Kinetics Following Exposure to High-Dose Methotrexate-Reference-Cited by-同舟云学术

Tissue Inhibitor Metalloproteinase-2 and Insulin-Like Growth Factor Binding Protein-7 Kinetics Following Exposure to High-Dose Methotrexate

Published:2023-03-08 Issue:5 Volume:4 Page:673-679
ISSN:2641-7650
Container-title:Kidney360
language:en
Short-container-title:Kidney360

Author:

Barreto Jason N.¹^ORCID,Barreto Erin F.¹^ORCID,Mara Kristin C.²,Rule Andrew D.³^ORCID,Lieske John C.³^ORCID,Giesen Callen D.⁴,Thompson Carrie A.⁵,Leung Nelson³^ORCID,Witzig Thomas E.⁵,Kashani Kianoush B.³^ORCID

Affiliation:

1. Department of Pharmacy, Mayo Clinic, Rochester, Minnesota

2. Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota

3. Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota

4. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota

5. Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota

Abstract

Key Points

Urinary TIMP2×IGFBP7 (uTIMP2×IGFBP7) concentrations experienced a rapid and sustained decline after high-dose methotrexate (MTX) exposure.

uTIMP2×IGFBP7 kinetics and concentrations after high-dose MTX exposure demonstrated no utility in predicting AKI.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Psychiatry and Mental health,Neuropsychology and Physiological Psychology

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