Healthy Women Have Higher Systemic Uromodulin Levels: Identification of Uromodulin as an Estrogen Responsive Gene-Reference-Cited by-同舟云学术

Healthy Women Have Higher Systemic Uromodulin Levels: Identification of Uromodulin as an Estrogen Responsive Gene

Author:

Nanamatsu Azuma¹^ORCID,Micanovic Radmila¹,Khan Shehnaz¹,El-Achkar Tarek M.¹²³^ORCID,LaFavers Kaice A.¹^ORCID

Affiliation:

1. Division of Nephrology and Hypertension, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana

2. Department of Anatomy, Cell Biology and Cellular Physiology, Indiana University School of Medicine, Indianapolis, Indiana

3. Roudebush VA Medical Center, Indianapolis, Indiana

Abstract

Key Points

Serum uromodulin levels are higher in healthy female participants than healthy male participants.

Serum uromodulin levels in participants with normal kidney function do not correlate with eGFR but do correlate with body mass index.

Estrogen increases uromodulin production, likely because of noncanonical and half estrogen response elements in the UMOD gene.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Psychiatry and Mental health,Neuropsychology and Physiological Psychology

Reference15 articles.

3. Serum uromodulin concentrations correlate with glomerular filtration rate in patients with chronic kidney disease;Fedak;Pol Arch Med Wewn.,2016

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