HISTOPATHOLOGICAL FEATURES IN RELAPSE OF ULCERATIVE COLITIS.

Abstract

Background and objective: To determine the frequencies of various histopathological features of relapse in previously diagnosed cases of ulcerative colitis . Methods: This was a Cross sectional study conducted at Histopathology department of Sheikh Zayed hospital Lahore from 1/6/2014 to 1/12/2014. Two hundred and seventy colonic biopsies were assessed using 3% margin of error and 95% of the confidence level. Patients clinically relapsed with ulcerative colitis including both genders in age group from 11 to 80 years were included. Biopsy specimen fixed in 10% formalin were received. Processing was done and sections stained with hematoxylin and were examined by the pathologist. College of Physicians and Surgeons Pakistan gave approval for this study. Data was then analyzed and entered by the SPSS version15. Results: Total number of patients were 270,out of which all of the patients have shown chronic inflammation and increase number of neutrophils in lamina propria (100%), focal lymphoid aggregate in 162/270(60%), increased number of eosinophils in lamina propria in 108/270(40%), cryptitis in 216/270(80%), crypt distortion in 202/270(75%), mucin depletion in151/270 (56%) and crypt abscess formation in 148/270(55%). Conclusion: Hence, cryptitis and crypt abscess were observed to be most commonly occurring significant and reliable featuress of relapse in ulcerative colitis.