Author:
TODUA NIKA,CHINCHARADZE DAVID,VACHNADZE NINA
Abstract
Approaching on comparative phytochemical screening tests of six species of Genus Mahonia Nuttall (Family Berberidaceae), which are introduced on the territory of Georgia, by productivity of biologically active alkaloids our attention deserves: Mahonia aquifolium (Pursh) Nutt., Mahonia bealei (Fort.) Carr; Mahonia japonica (Thunb.) DC.; Mahonia wagneri Join.After studying samples with alkaloids on thin layer chromatography compared with standard solutions, there were identified isoquinoline alkaloids such as: berberine, jatrorrhizine, palmatine, magnoflorine, berbamine and colchicine. The total substance obtained from the vegetative organs of Mahonia aquifolium (Oregon grape) were evaluated for in vitro cytotoxicity against cells of lung carcinoma lines (A-549), colon adenocarcinoma (DLD-1) and normal human fibroblasts (WS-1). As a result, the investigated fractions showed pronounced activity against all cell lines.
Publisher
Association For Science (Publications)
Reference17 articles.
1. Димитриева А.А. Определитель растений Аджарии. Тбилиси, Мецниереба, 1990, 1, 328.
2. Пилипенко Ф.С. Иноземные деревья и кустарники на Черноморском побережье Кавказа. Л., Наука, 1978, 286.
3. Флора Грузии, Тбилиси, Мецниереба, 1983, 376.
4. Jian-Ming He, Qing Mu. The medicinal uses of the genus Mahonia in traditional Chinese medicine: An ethnopharmacological, phytochemical and pharmacological review. Journal of Ethnopharmacology, 2015, 175, 668–683.
5. Flora of China Editorial Committee, 2001. Flora of China. Science Press, Beijing.