Affiliation:
1. Institute of Endocrine and Metabolic Sciences, IRCCS San Raffaele Hospital, Milan, Italy
2. Nuclear Medicine Department, IRCCS San Raffaele Scientific Institute, Milan, Italy
Abstract
ormocalcemic primary hyperparathyroidism is a recently distinguished form of Primary hyperparathyroidism and it is mostly caused by an hyperfunctioning parathyroid adenoma. It has been consistently associated with skeletal and renal complications, and, therefore, a proper radiological diagnosis of the hyperfunctioning adenoma is crucial in patients affected. Here we report a case of a patient affected by normocalcemic primary hyperparathyroidism and a severe osteoporosis complicated with multiple fragility fractures, highlighting the role of PET-choline in the diagnosis of an hyperfunctioning cervical-mediastinal parathyroid adenoma not previously localized with conventional imaging. KEY WORDS: PET-choline, normocalcemic hyperparathyroidism, osteoporosis, fractures, parathyroid adenoma.
Reference10 articles.
1. 1. Giustina A, Formenti AM, Napoli N. Malattie delle paratiroidi. Medicina Interna Sistematica - Rugarli C, Cappelli G, Cappellini MD, Perin PC, Corazza GR, Craxì A, Crea F, Fabbri LM, Ferraccioli G, Ghia P, Giustina A, Lazzarin A, Nuti R, Pardi R, Stella AP. EDRA. Ottava Edizione (2021). ISBN 8821450953.
2. 2. Bilezikian JP, Cusano NE, Khan AA, Liu JM, Marcocci C, Bandeira F. Primary hyperparathyroidism. Nat Rev Dis Primers. 2016;2:16033.
https://doi.org/10.1038/nrdp.2016.33
3. 3. Cusano NE, Cipriani C, Bilezikian JP. Management of normocalcemic primary hyperparathyroidism. Best Pract Res Clin Endocrinol Metab. 2018;32(6):837-45.
https://doi.org/10.1016/j.beem.2018.09.009
4. 4. Zavatta G, Clarke BL. Normocalcemic hyperparathyroidism: a heterogeneous disorder often misdiagnosed? JBMR Plus. 2020;4(8):e10391.
https://doi.org/10.1002/jbm4.10391
5. 5. Graves CE, Duh QY, Suh I. Innovations in parathyroid localization imaging. Surg Oncol Clin N Am. 2022;31(4):631-47.
https://doi.org/10.1016/j.soc.2022.06.004