Affiliation:
1. Moscow State University
Abstract
This review is devoted to the consideration of pathological intracellular mechanisms characteristic of Huntington’s disease and the central role of huntingtin protein in these processes. The features of mutant huntingtin aggregates utilization by the ubiquitin-proteasome system and autophagy, as well as the possibilities of polyglutamine-containing substrates hydrolysis by proteasome are discussed.