GLYCOLIPOTRIPEPTIDE (N-LACTITOL-Gly)2-LysС16 AND ITS FLUORESCENTLY LABELED ANALOGUE FOR VISUALIZATION OF VECTOR SYSTEMS FOR BIOLOGICALLY ACTIVE SUBSTANCES DELIVERY TO TARGET CELLS-Reference-Cited by-同舟云学术

GLYCOLIPOTRIPEPTIDE (N-LACTITOL-Gly)2-LysС16 AND ITS FLUORESCENTLY LABELED ANALOGUE FOR VISUALIZATION OF VECTOR SYSTEMS FOR BIOLOGICALLY ACTIVE SUBSTANCES DELIVERY TO TARGET CELLS

Published:2023-11-07 Issue:№5, 2023 Volume:64 Page:478-489
ISSN:1728-2101
Container-title:Lomonosov chemistry journal
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Author:

Afanasyeva Ksenia A.¹,Gileva Anastasia М.²,Markvicheva Elena A.²,Budanova Ulyana A.¹,Sebyakin Yurii L.¹

Affiliation:

1. MIREA – Russian Technology University (Lomonosov Institute of Fine Chemical Technology)

2. Institute of Bioorganic Chemistry, academicians M.M. Shemyakin and Yu.A. Ovchinnikov RAS

Abstract

The work is devoted to the preparation of a carbohydrate derivative of lipotripeptide (N-lactitol-Gly)2-LysC16 of irregular structure with two terminal residues of D-galactose, a branching link based on aliphatic L-lysine and its carbohydrate-free analog with 1-pyrenbutanol as a fluorescent label in a hydrophobic fragment. The developed synthesis scheme includes universal approaches of peptide chemistry, as well as the stages of formation of an acyclic carbohydrate based on lactose in the hydrophilic domain of amphiphile. The compounds are designed to create compositions of vector BAS delivery systems with the ability to visualize the process of interaction with target cells.

Funder

Ministry of Education and Science of the Russian Federation

Publisher

Moscow University Press

Subject

General Chemistry

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