TUMOR CELL PANEL WITH CHARACTERIZED EXPRESSION OF PD-L1 FOR PRECLINICAL STUDIES OF ANTICANCER DRUGS AND IMMUNE CHECKPOINT INHIBITORS INTERACTION-Reference-Cited by-同舟云学术

TUMOR CELL PANEL WITH CHARACTERIZED EXPRESSION OF PD-L1 FOR PRECLINICAL STUDIES OF ANTICANCER DRUGS AND IMMUNE CHECKPOINT INHIBITORS INTERACTION

Published:2023-06-01 Issue:№1, 2023 Volume:64 Page:26-34
ISSN:1728-2101
Container-title:Lomonosov chemistry journal
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Author:

Bogush T.A.¹,Basharin A.A.¹,Scherbakov A.M.¹,Chandran K.I.¹,Mikhailova A.L.¹,Romanov I.P.²,Bogush E.A.³,Kosorukov V.S.¹

Affiliation:

1. Federal State Budgetary Scientifi c Institution “N.N. Blokhin National Medical Research Center of Oncology” of the Ministry of Health of the Russian Federation, Moscow, Russia

2. Lomonosov Moscow State University, Moscow, Russia

3. The State Education Institution of Higher Professional Training The First Sechenov Moscow State Medical University under Ministry of Health of the Russian Federation, Moscow, Russia

Abstract

PD-L1 (Programmed death-ligand 1), a membrane protein of the immunoglobulin superfamily, is one of the targets for cancer immunotherapy. A panel of 14 cancer cell cultures with different constitutive PD-L1 expression level was formed and characterized. The panel is recommended for preclinical studies of a cytostatic drug effect on PD-L1 expression and for predicting the ef cacy of their combination with immune checkpoint inhibitors.

Funder

Ministry of Science and Higher Education of the Russian Federation

Publisher

Moscow University Press

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