DIVERSITY OF H2A HISTONES AND THEIR IMPLICATIONS FOR NUCLEOSOME STRUCTURAL PROPERTIES

Author:

SINGH-PALCHEVSKAIA L.1ORCID,SHAYTAN A.K.1ORCID

Affiliation:

1. Lomonosov Moscow State University

Abstract

Histone proteins are key epigenetic factors, which play an important role in chromatin dynamics and gene activity regulation. They are divided into two broad classes: canonical histones and their variants. Canonical histones are expressed mainly during the S-phase of the cell cycle, as they are involved in DNA packaging during cell division. Histone variants are histone genes that are expressed and regulate chromatin dynamics throughout the cell cycle. Due to the functional and species diversity, various families of histone variants are distinguished. Some proteins may diff er slightly from canonical histones, while others, on the contrary, may have many important structural and functional features that aff ect nucleosome stability and chromatin dynamics. In order to assess the variability of the H2A histone family and their role in nucleosome structure, we performed a bioinformatic analysis of the amino acid sequences of the H2A histone family. The clustering performed by the UPGMA method made it possible to reveal two main subfamilies of H2A proteins: short H2A and other H2A variants demonstrating highly conserved amino acid sequences. We also constructed and analyzed multiple alignments for various H2A histone subfamilies. It is important to note that the proteins of the short H2A subfamily are not only the least conserved within the H2A family, but also have features that signifi cantly aff ect the structural properties of the nucleosome. In addition, we performed a phylogenetic analysis of short H2A, which resulted in the identifi cation and characterization of individual clades on the phylogenetic tree for the variants H2A.B, H2A.P, H2A.Q, H2A.L.

Funder

Ministry of Science and Higher Education of the Russian Federation

Publisher

Moscow University Press

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3