Small-molecule fluorescence-based probes for aging diagnosis

Author:

Shi Donglei12,Liu Wenwen3,Wang Guangwei2,Guo Yuan2,Li Jian1345

Affiliation:

1. State Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China

2. College of Chemistry and Materials Science, Northwest University, Xi’an 710127, China

3. Key Laboratory of Tropical Biological Resources of Ministry of Education, College of Pharmacy, Hainan University, Haikou 570228, Hainan, China

4. Yunnan Key Laboratory of Screening and Research on Anti-Pathogenic Plant Resources from West Yunnan, College of Pharmacy, Dali University, Dali 671000, China

5. Clinical Medicine Scientific and Technical Innovation Center, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200092, China

Abstract

Aging is a time-dependent decline in physiological function that affects most organisms and is the major risk factor for many non-communicable diseases. The early diagnosis of aging is critical for the treatment of aging and aging-related diseases. In recent years, extensive efforts have attempted to accurately diagnose aging. To date, multiple types of fluorescent probes for various age-related biomarkers have been developed, with the aims of achieving rapid, precise diagnosis of the aging process and evaluating the efficacy of anti-aging drugs. This review summarizes recent research progress in small-molecule fluorescence-based probes for aging diagnosis, and further discusses the challenges and opportunities in this field.

Publisher

Compuscript, Ltd.

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