Ondansetron and Hypothermia Induced Cardiac Arrest in a 97-Year-Old Woman: A Case Report

Author:

Leung Keith Sai Kit1,Ahmad Faareaha1,Mahmood Amun1,Shum Yuki Ka Ling1,Punj Ekta2,Majeed Azam2,Hosein Riad2,Hong Anna2,Hashmi Muzaffar2

Affiliation:

1. Faculty of Health and Life Sciences, Aston University, Birmingham B4 7ET, United Kingdom

2. Emergency Department, Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Birmingham B15 2TH, United Kingdom

Abstract

Background: Ondansetron and hypothermia are both known to induce bradycardia or QT interval prolongation, thus placing affected patients at risk of cardiac arrest. Case Report: Herein, we report the case of a 97-year-old woman who initially presented with confusion and hypothermia, and experienced severe bradycardia and asystolic cardiac arrest after a 4 mg intravenous ondansetron bolus injection. Conclusion: Ondansetron is associated with bradycardia and QTc prolongation, both of which might be further exacerbated by hypothermia. Clinicians should be aware that administering ondansetron in patients with hypothermia might further increase the risk of adverse cardiac events and eventual cardiac arrest.

Publisher

Compuscript, Ltd.

Subject

General Medicine

Reference14 articles.

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