Primary bone lymphoma of proximal tibia presenting with pathological fracture: A case report

Abstract

Abstract Primary bone lymphoma (PBL) is an uncommon tumor accounting for approximately 4%–5% of extranodal lymphoma and less than 2% of all non-Hodgkin’s lymphoma. Diffuse large B-cell lymphoma is the most common pathological type, comprising nearly 80% of PBL. We report a case of a 35-year-old male presented to outpatient department with a pathological fracture of the left proximal tibia secondary to primary B-cell lymphoma. Initially, the clinical presentation simulated chronic osteomyelitis, but on further workup, it comes to be a case of histopathological and immunohistochemistry confirmed primary B-cell lymphoma of the left proximal tibia. He was managed with chemotherapy. There is clinical improvement in terms of pain and swelling with no preternatural adverse effects of chemotherapy. Although the incidence of PBL is very rare, in view of good treatment response to the chemotherapy, as in our case, PBL should be kept in mind as a differential diagnosis; workup should be done accordingly by applying appropriate immunohistological markers for early diagnosis and treatment.