What is the ideal preconditioning time to reduce laparoscopic-induced oxidative stress?

Author:

Yazicioglu Murat Burc1,Eraldemir Fatma Ceyla2,Gunes Abdullah1,Turgut Hamdi Taner1,Ciftci Ali1

Affiliation:

1. Department of General Surgery, Kocaeli Derince Training and Research Hospital, University of Health Science, Kocaeli, Turkey

2. Department of Biochemistry, School of Medicine, University of Kocaeli, Kocaeli, Turkey

Abstract

Introduction: Ischaemic preconditioning is the most effective method for the prevention of ischaemic-reperfusion injury; however, no study has examined the question of the ideal time for ischaemic preconditioning. Patients and Methods: The patients were divided into five groups, each group including of 20 patients. The precondition was applied as 1, 5, 10 and 15 min in Groups I, II, III and IV and Group V was the control group. Repeated blood samples were taken to measure the total antioxidant status (TAS), total oxidant status and oxidative stress index (OSI) values, just before insufflation, at the end of the operation and at 6 and 24 h of the post-operative period. Results: A significant difference was observed between the TAS values at the end of the operation and at the sixth post-operative time of the four groups (P = 0.001, 0.000, 0.001, 0.019 and 0.033, respectively). Furthermore, a significant difference was observed between TAS values at the post-operative 24th h of Group III and Group V, and also a significant difference was observed between the OSI values at the post-operative 6th h of Groups III and V. Conclusion: The low OSI and TAS values may interpret as a low degree of oxidative damage. The OSI values at the post-operative 6 h of Groups I and II were lower than those of other groups. We accept this result as low oxidative damage.

Publisher

Medknow

Subject

Surgery

Reference29 articles.

1. Preconditioning is a method that may reduce the negative side-effect of pneumoperitoneum;Jávor;Interv Med Appl Sci,2010

2. The effect of different intraabdominal pressures on lipid peroxidation and protein oxidation status during laparoscopic cholecystectomy;Polat;Surg Endosc,2003

3. Ischemic preconditioning decreases laparoscopy induced oxidative stress in the liver;Nesek-Adam;Coll Antropol,2010

4. Protection of the liver by ischemic preconditioning: A review of mechanisms and clinical applications;Koti;Dig Surg,2003

5. Systematic review of oxidative stress associated with pneumoperitoneum;Sammour;Br J Surg,2009

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