Affiliation:
1. Department of Medical Research, Tungs’ Taichung MetroHarbor Hospital, Taichung, Taiwan
2. Department of Nursing, Tungs’ Taichung MetroHarbor Hospital, Taichung, Taiwan
3. Department of Respiratory Therapy, Ching-Chyuan Hospital, Taichung, Taiwan
4. Department of Endocrinology and Metabolism, Tungs’ Taichung MetroHarbor Hospital, Taichung, Taiwan
5. Department of Pediatrics, Tungs’ Taichung MetroHarbor Hospital, Taichung, Taiwan
Abstract
Abstract
Background:
Severe acute respiratory syndrome coronavirus (SARS-CoV)-2, which is a novel coronavirus from the same family as SARS-CoV and Middle East respiratory syndrome coronavirus, has overrun worldwide leading the World Health Organization to declare a pandemic.
Objectives:
This study aimed to clarify high-risk factors for coronavirus disease 2019 (COVID-19) with multivariate analysis and establish a predictive model of disease progression to help clinicians better choose a therapeutic strategy. Clinical implications of COVID-19 will push society past this pandemic with the latest in technology and research and further studies into the pathogenesis evaluation.
Methods:
A comprehensive search of the PubMed, MEDLINE, Uptodate, Natural MEDLINE, Embase, and Web of Science electronic databases was made, using the following search terms: “COVID-19,” “COVID-19 SCORE,” “COVID-19 diagnosis,” “COVID-19 management,” “coronavirus,” and “SARS-CoV-2.” We included scientific publications from December 1, 2019, to April 31, 2021, which focused on clinical characteristics and treatments for SARS-CoV-2 that were eligible for inclusion. We screened all reference lists of relevant studies to identify any missing publications.
Results:
A total of 40 articles were reviewed. We revealed that the present review emphasizes that the higher risk of comorbidity, age, lymphocyte, and lactate dehydrogenase (CALL) score has a good predictive value for mortality in COVID-19 than the CURB-65 score. The 2021–2022 SARS-CoV-2 Omicron variant is a global concern due to its rapid spread to displace the main Delta and Omicron variants. This scoring system has been designed to categorize based on the systemic disease involvement and, thus, would serve as a reliable indicator for prognostic assessment in patients.
Conclusion:
This review highlights the higher predictive value of the CALL score for higher risk COVID-19 mortality than the CURB-65 score. The 2021–2022 SARS-CoV-2 Omicron variant is of global concern as its rapid spread has replaced the main Delta and Alpha variants. Scoring systems are designed to categorize disease and, thus, serve as reliable indicators of patient prognosis. Therefore, establishing corresponding standard assessment forms and admission criteria and preparing medical resources for critically ill patients is necessary as much as possible.