A Comparison of the Effectiveness of Concentrated Growth Factors-Enriched Bone Graft Matrix (Sticky Bone) and Type-1 Collagen-Derived (DMBM) Xenograft Coated with a Resorbable-Guided Tissue Regeneration Membrane: A Clinico-Radiographic Study on Intrabony Defects

Abstract

Background: The main goals of periodontal treatment are to gain access to the diseased areas, reduce pocket depth, stop the disease’s progression, and then repair the periodontal tissues that have been harmed by the disease process. Our study compared the efficacy of Type-1 collagen-derived (DMBM) Xenograft Coated with a resorbable-guided tissue regeneration (GTR) membrane and enriched bone graft matrix with concentrated growth factors (CGFs) (Sticky Bone) in the treatment of periodontal infrabony defects. Methodology: The study included 40 patients with periodontal infrabony defects who were systemically healthy. According to clinical and radiographic measurements, two groups to which the defects were randomly assigned at the time of surgery Group II Type-1 collagen-derived (DMBM) xenograft coated with a resorbable GTR membrane and Group I-enriched bone graft matrix with CGFs (Sticky Bone). Results: At the 6month examination, probing pocket depth reduction was moderately significant in the Group I (7.43 ± 1.51 mm to 3.00 ± 1.53 mm) compared with the Group II (7.14 ± 0.69 mm to 3.00 ± 1.53 mm). The mean gains of clinical attachment were 8.29 ± 1.98 mm to 3.86 ± 1.46 mm in the Group I and 7.85 ± 0.69 mm to 4.53 ± 1.113 mm in the Group II. Radiographic defect depth reduction was slightly greater in the Group I compared with the Group II. Conclusions: According to the findings of this study, treating infrabony defects with unfavorable architecture using a Sticky Bone with CGF membrane in combination with bone graft has significantly improved all clinical parameters tested when compared to using a GTR membrane.