Author:
Naseem Shano,Murgai Pooja,Varma Neelam,Varma Subhash
Abstract
We report a case of AML in a 29-year-old HIV-positive female on anti-retroviral therapy. She presented with bicytopenia, fever and easy fatiquability. Bone marrow examination revealed 77% blasts, which on flow cytometric immunophenotyping showed positivity for myeloid lineage markers and were negative for monocytic and lymphoid lineage markers. Although rare, AML is seen in HIV patients, therefore, in presence of persistent cytopenias, detailed hematological evaluation should be done so as to not miss/delay the AML diagnosis.
Subject
Radiology, Nuclear Medicine and imaging,Oncology,General Medicine
Reference24 articles.
1. Acquired immunodeficiency syndrome-related lymphoma;Levine;Blood,1992
2. B cell acute lymphocytic leukemia in adults. Clinical, morphologic, and immunologic findings;Gill;J Clin Oncol,1986
3. Multiple myeloma in two HIV-infected patients;Faure;AIDS,1999
4. Is Nef the elusive cause of HIV-associated hematopoietic dysfunction?;Kirchhoff;J Clin Invest,2008
5. The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha5beta1 and alphavbeta3 integrins and by mobilizing sequestered basic fibroblast growth factor;Barillari;Blood,1999