Evaluation of Thrombin Activatable Fibrinolysis Inhibitor (TAFI) in Patients with β-Thalassemia

Author:

Abdulsattar Mohammed Qasim,Al-Mudallel Subh Salim

Abstract

Background: Thalassemia is an inherited disorder of hemoglobin (Hb) synthesis that results in reduced or absent production of globin chain. Hypercoagulable state in thalassemia is a well-recognized event. Thrombin activatable fibrinolysis inhibitor (TAFI) is an enzyme considered to play an important role in the regulation of fibrinolysis by the coagulation system. With this background, the present study was conducted to know the role of TAFI as a contributing factor in hemostatic alteration state in adults with β-thalassemia. Aim: The aim of this article is to evaluate the level of TAFI and hematological parameters in splenectomized and non-splenectomized β-thalassemia patients and to compare their levels with normal subjects. Materials and Methods: This case–control study was conducted in 56 adult thalassemic patients. The plasma TAFI level was evaluated by the ELISA technique. Results: There was a significant reduction in TAFI levels in all thalassemic patients when compared with thalassemia minor patients and controls (P < 0.0001). The TAFI level was significantly lower in the splenectomized group when compared with the non-splenectomized group (P < 0.0001), and the TAFI level was significantly lower in the thalassemia major group when compared with the thalassemia intermediate group (P < 0.0001). There was a significantly higher prothrombin time and activated partial thromboplastin time level in thalassemic major and intermediate patients when compared with thalassemia minor patients and controls (P < 0.001). Conclusion: The TAFI enzyme level could be an important predictor for hemostatic alteration. Its level can be considered as a helpful marker for monitoring and follow-up of thalassemic patients for early and proper intervention to minimize complications.

Publisher

Medknow

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3