The Relationship between Leptin Hormone and Central Obesity in the Women Suffers from Polycystic Ovary Syndrome: A Case–Control Study

Abstract

Abstract Background: One of the hallmarks of polycystic ovarian syndrome (POCS) is central obesity (CO), and conditions brought on by PCOS are likely to worsen when CO is present. The hormone leptin acts as a conduit to transmit metabolic signals from the brain’s neural networks to the pituitary-ovarian axis. Objective: It is to find the correlation between central adiposity and blood levels of leptin in women with PCOS. Materials and Methods: For this study, 150 women were recruited: 75 were control (n = 75) and 75 were PCOS (n = 75). The body mass index (BMI); waist circumference; hip circumference; waist/hip ratio and level of circulating serum leptin were assessed for each individual. The data analysis was conducted utilizing SPSS software (version 23). Results: Leptin hormone, a higher significant in the group of PCOS when compared with the control group (P > 0.05). A positive significance correlation was found between the level of leptin with BMI, waist circumference, and hip circumference (P < 0.05). Leptin level showed an AUC of 0.93 at a cutoff point of 10 ng/mL, giving a sensitivity (93%) and specificity (96%). Conclusion: The positive association between serum leptin and CO with BMI could be the cause of the increased leptin levels in the PCOS women.