Identifying the effect of vitamin D on the HbA1c in patients of type 2 diabetes mellitus in Mosul city

Abstract

Abstract Background: Diabetes mellitus causes metabolic disturbances and defectiveness in most tissues and cells of the body, especially in the nerves, blood vessels, eyes, kidneys, and other body tissues. It is known that type 2 diabetes mellitus is one of the most prevalent diseases in the city of Mosul, due to several reasons, such as excessive carbohydrate intake, psychological disorders, obesity, and lack of exercise. Because of these and other reasons, there was a need to conduct scientific research to clarify the main reasons for diabetes, modify the method of treatment and change the lifestyle to avoid falling into these chronic diseases. Objective: Studying the effect of vitamin D deficiency on patients with type 2 diabetes mellitus for the population of Mosul city for the purpose of modifying the metabolism in the body. Materials and Methods: Fifty eight study subjects were collected from patients with type 2 diabetes mellitus (diagnosed by a specialist and HbA1c test results) with 20 control samples of approximately the same ages and body mass index. Thereafter, We have investigate the durations of improving vitamin D for more than one year and record all medical history of the patients. Eleven study subjects were excluded due to drug interactions. Forty nine subjects of a study comprised 33 females and 16 males who were included in the study after making sure that they did not take medication. None of them were pregnant or breastfeeding. Their mean age was (51.8 ± 0.2 years) and their mean BMI was (26.8 ± 0.5). The examination was carried out using immunofluorescence and dry chemistry using the I CHROMA TM II device with the materials of the device, which were provided by the manufacturer with all the materials for calibration and quality control. Results: Forty nine study subjects were examined by HbA1c and vitamin D level by immunofluorescence technique, and the mean results were (9.3 ± 0.1%) for HbA1c and (14.3 ± 1 ng/mL) for vitamin D. After treatment with vitamin D for 1 month. The results showed a good improvement in the results of the HbA1c examination, as their average results were (7.1 ± 0.1%), with an improvement in the results of the vitamin D examination by (48.8 ± 1 ng/mL). Conclusions: There was a clear improvement in the level of sugar in the blood of patients with type 2 diabetes mellitus after treatment with vitamin D and an improvement in its level in the blood.