Comparison of two dosage regimens of iron in preterm infants for the prevention of iron deficiency: A prospective interventional study

Author:

Asha S.1,Anand M.R.1,Remesh Preetha2,Vishnu Mohan P.T.1

Affiliation:

1. Department of Paediatrics and Neonatology, ASTER MIMS, Calicut, Kerala, India

2. Department of Neonatology, ASTER MIMS, Calicut, Kerala, India

Abstract

Abstract BACKGROUND: The majority of infants born <32 weeks of gestation develop anemia. The cause depends on multiple factors, most common being iron deficiency. Iron being a major nutrient, its deficiency may lead to irreversible neurodevelopment and cognitive impairment and overdose lead to neurodegeneration and gastrointestinal intolerance. Although the need for iron and outcome of iron deficiencies has been studied much, valid studies pertaining dosage for prevention of iron deficiency in preterm infants are insufficient. OBJECTIVE: To compare two dosage regimens of iron for the prevention of iron deficiency among preterm infants born <32 weeks at 6 weeks of chronological age. MATERIALS AND METHODS: A prospective interventional study performed in a level III neonatal intensive care unit. A total of 64 infants with <32 weeks of gestation were studied, were classified into two grouped, and initiated with iron at two different doses (2 and 4 mg/kg/day). The preintervention and postintervention hemoglobin and serum ferritin were compared at 6 weeks of chronological age. RESULTS: Of the 32 babies with iron initiated at 2 mg/kg/day, 21 babies had low hemoglobin level and 11 babies had normal hemoglobin level, and 10 babies had low ferritin level and 22 babies had normal ferritin level. Of the 32 babies with iron at 4 mg/kg/day, all babies had normal hemoglobin and ferritin levels. Conclusion: The incidence of anemia is lower in the infants receiving iron at 4 mg/kg/day compared with infants receiving iron at 2 mg/kg/day.

Publisher

Medknow

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3