Evaluation of the activated partial thromboplastin time, prothrombin time, and international normalized ratio among pregnant women attending selected hospitals in Mogadishu, Somalia

Abstract

Abstract Background Despite the fact that many prior investigations of Hemostasis parameters during pregnancy have already been conducted in many different parts of the world, In Somalia, there is a lack of studies investigating coagulation changes in healthy pregnant women. This study aimed to assess hemostatic parameters [especially prothrombin time (PT), INR, and activated partial thromboplastin time (APTT)] among pregnant women at selected hospitals in Mogadishu, Somalia. Method This study’s design was cross-sectional. With informed consent, about 200 pregnant women were chosen to take part in the study. 2.5 ml of blood samples were then obtained using trisodium citrate anticoagulant and measured Coagulometry hemostasis device. The study group that had known hemostatic abnormalities was not included. I analyzed the results using SPSS. Results The study’s target demographic (61.0%) was between the ages of 20 and 30. Most of the study group (53.5%) weighed between 75 and 84 kg, and 193 (96.5%) were married. According to the study, 193 (96.5%) of individuals had never had their hemostatic profiles checked before. About 86.5% of people had no formal schooling. Most pregnant women had normal PT levels, which were 149 (74.5%), while those with low levels were 42 (21.0%), and those with high levels were 9 (4.5%). 153 (76.5%) of pregnant women had normal APTT levels, while 6 (3.1%) had high APTT levels and 41 (20.5%) had low APTT levels. Conclusion The study findings show that most pregnant women had normal levels of APTT and PT, indicating appropriate coagulation function. However, a portion of the participants had high or low levels, which may indicate an increased risk of bleeding or thrombotic complications. It is crucial to monitor APTT and PT levels during pregnancy to identify individuals who may require medical intervention. By managing and addressing specific APTT and PT levels, healthcare providers can optimize the health outcomes of both the mother and the fetus.