Hematological indices among young adults with homozygous sickle cell disease in steady state in southwestern Nigeria: a case–control study

Author:

Asafa Muritala A1,Ahmed Ibrahim O2,Umar Abubakar S2,Bolarinwa Rahman A23,Ogunlade Oluwadare1

Affiliation:

1. Department of Physiological Sciences, Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife, Nigeria

2. Department of Haematology and Blood Transfusion, Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife, Nigeria

3. Haematology and Immunology, Faculty of Basic Medical Sciences, College of Health Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria

Abstract

Abstract Background: Sickle cell disease is a genetic abnormality involving the haemoglobin synthesis. Although it is a primary red cell disorder, white blood cells (WBC) and platelets are also affected by the mutation. Aim: To assess and compare the hematological parameters of homozygous sickle cell disease in a steady state with age-matched and sex-matched hemoglobin AA controls. Methods: A total of 150 apparently healthy young adults (18–35 years) participated in this study. They were classified into two groups 88 cases with hemoglobin SS and 62 controls. Venous blood collected into EDTA tubes from participants were used for the full blood count analysis which was done using hematological autoanalyzer (SFRI blood cell counter, H18 light, France). The data were analyzed using descriptive and inferential statistics and the alpha value was set at P value less than 0.05. Results: The mean values for white blood cell, mean corpuscular hemoglobin, mean cell volume, red cell distribution width and platelet count were significantly higher in the Hb SS cohort while the packed cell volume and red cell count were significantly lower in the Hb SS cohort. Conclusions: homozygous sickle cell disease patients have lower values of hemoglobin concentration, PCV, the red cell indices but higher values of white cell count and platelets compared with hemoglobin phenotype AA controls.

Publisher

Medknow

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