Evaluation of hepatic fibrosis by transient elastography in βthalassemia children before and after hematopoietic stem cell transplantation

Author:

Salama Reem1,Elhawary Eslam2,Ziada Dina3,Elshanshory Mohamed1,Elkaffas Asmaa2

Affiliation:

1. Pediatric Department, Faculty of Medicine, Tanta University, Tanta, Egypt

2. Pediatric Hematology/Oncology and Bone Marrow Transplantation Unit, Pediatric Department, Faculty of Medicine, Tanta University, Tanta, Egypt

3. Tropical Medicine Department, Faculty of Medicine, Tanta University, Tanta, Egypt

Abstract

Abstract Background Iron overload is a major concern in all patients with transfusion-dependent thalassemia (TDT). The liver, being a target for iron deposition is at risk of developing liver fibrosis or even cirrhosis. Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative treatment in clinical practice, a process that is surrounded by several precautions and complications that may affect the liver condition as well. Aim To evaluate the degree of hepatic fibrosis in children with TDT before and after HSCT. Methodology Twenty-five children with TDT who underwent HSCT were investigated by serum ferritin in addition to the assessment of liver fibrosis using transient elastography by FibroScan and liver fibrosis scores before and 1-year after HSCT. Results Out of the 25 children enrolled, only 16 completed a 1-year post-transplantation follow-up period. Slightly increased liver stiffness values measured by FibroScan 1-year post-transplantation, but the patients were still having the same degree of fibrosis of the pre-transplant period. FIB-4 score and APRI also showed statistically significant increase post-transplant as compared to pre-transplantation. Conclusion Stationary degree of fibrosis in thalassaemic children after HSCT with slight increases in the liver stiffness values by transient elastography that necessitates longer follow-up of the fibrosis status of patients’ post-transplant. Transient elastography is considered a helpful noninvasive tool for assessment of the hepatic status before and after HSCT.

Publisher

Medknow

Reference16 articles.

1. Prevalence, incidence, trend, and complications of Thalassemia in Iraq;Kadhim;Hemoglobin,2017

2. Long-term complications after hematopoietic cell transplantation;Majhail;Hematol Oncol Stem Cell Ther,2017

3. Bone marrow transplantation in thalassemia: the experience of Pesaro;Lucarelli;Ann N Y Acad Sci,1998

4. Transient elastography: a new noninvasive method for assessment of hepatic fibrosis;Sandrin;Ultrasound Med Biol,2003

5. Prospective comparison of transient elastography, MRI and serum scores for grading steatosis and detecting non-alcoholic steatohepatitis in bariatric surgery candidates;Garteiser;JHEP Rep,2021

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3