Correlation of Anti-Mullerian Hormone with Antral Follicle Count among South Indian Infertile Women in a Tertiary Care Center

Abstract

Context: Diminished ovarian reserve (DOR) is one of the important causes of infertility and its incidence is increasing even in younger age groups with no risk factors. Ovarian reserve needs to be evaluated in an infertile couple as the fecundity or response to ovarian stimulation is less in women with DOR. Anti-Mullerian hormone (AMH) and antral follicle count (AFC) are markers of ovarian reserve with the highest sensitivity. Aims: The aim of this study was to assess the ovarian reserve among infertile women through AMH and AFC, to find if there is a correlation between AMH and AFC, and to see if there is a correlation between AMH and AFC with age. Settings and Design: This study was conducted at the Department of OBG, JSS Hospital, JSS AHER, Mysore. This was a cross-sectional study. Materials and Methods: The study included 141 infertile women aged 19–45 years. Serum AMH was measured using chemiluminescent immunoassay irrespective of the day of the menstrual cycle and AFC was measured on 2nd or 3rd day of the menstrual cycle by transvaginal ultrasound. Statistical Analysis Used: Student’s-t-test, Chi-square test, and Pearson’s correlation were used for analysis. Results: Mean AMH and AFC of the subjects were 4.52 ± 4.16 ng/ml and 17.08 ± 12.54, respectively. A significant positive correlation was noted between AMH and AFC (r = 0.663, P < 0.01) and there was a significant negative correlation between age as compared with AFC (r = −0.349, P < 0.01) and AMH (r = −0.244, P < 0.01). Conclusion: AFC and AMH showed a significant negative correlation with age. AFC had a strong positive correlation with serum AMH.