Affiliation:
1. Department of Internal Medicine, College of Medicine, Najran University, Najran, Saudi Arabia
2. Department of Physiology, College of Medicine, King Khalid University, Abha, Saudi Arabia
Abstract
Background:
Globus pharyngeus is a clinical condition, wherein, a patient senses a lump or a foreign body in the throat with a tightening or choking feeling. A strong association between globus pharyngeus and gastroesophageal reflux disease (GERD) was reported. Therefore, we sought to investigate the predictive factors of globus pharyngeus in patients with established GERD and fit a predictive scoring model for globus pharyngeus.
Methods:
In this case-control study, 143 patients having globus pharyngeus along with GERD (case) and 109 patients having globus pharyngeus without GERD (control) were enrolled. Data comprising demographics, comorbidities, and psychosocial stress levels were recorded. The predictive factors of globus pharyngeus in patients with GERD were unraveled, and a predictive scoring model was fit for globus pharyngeus.
Results:
Proton pump inhibitor usage in the case group was significantly higher compared to controls (63.63% vs 24.78%, P < 0.001), and differences in Hiatus Hernia and Stress levels were highly significant between the two groups (P < 0.001). Multivariate logistic regression revealed that variates, Hiatus Hernia, psychosocial stress, and age were highly significant (P < 0.001) independent predictors of globus pharyngeus. Using the regression coefficients of all the independent predictor variables, a predictive scoring model was fitted, which yielded an area under receiver operating characteristic (AUROC) curve of 78.9.
Conclusion:
Hiatus hernia, psychosocial stress, and age are significant independent predictors of globus pharyngeus in GERD, and our predictive scoring model may help in identifying patients at higher odds of experiencing globus pharyngeus and modulate treatment accordingly.
Reference42 articles.
1. The globus symptom. Incidence, therapeutic response, and age and sex relationships;Moloy;Arch Otolaryngol,1982
2. Householder survey of functional gastrointestinal disorders. Prevalence, sociodemography, and health impact;Drossman;Dig Dis Sci,1993
3. The natural history of Globus Pharyngeus;Rowley;Laryngoscope,1995
4. Gastroesophageal reflux, motility disorders, and psychological profiles in the etiology of globus pharyngis;Hill;Laryngoscope,1997
5. Globus sensation and gastroesophageal reflux;Chevalier;Eur Arch Otorhinolaryngol,2003
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献