Clinicopathological, Hematological, and Hepatorenal Function Tests in People Affected with Esophageal Cancers at the Time of Diagnosis: Observations from an Oncology Center

Abstract

ABSTRACT Objective: Oesophageal cancer (OC) is the sixth most widespread cancer in the world. It has low prognostic rate and hence associated with high mortality. There are very few studies that have compared the clinical parameters between healthy individuals and OC patients. In this study, an attempt was made to understand the variations in the hematological, liver, and kidney function parameters in these patients who were yet to begin their treatment. Materials and Methods: This study was undertaken with a group of healthy and OC diagnosed individuals from both genders (male and female). The blood was collected using a vacutainer and various hematology parameters were ascertained using a fully automated three-part differential cell counter. The liver and kidney function tests for various targets were analyzed using the commercial diagnostic kits as per the manufacturer’s protocols. Results: When compared to healthy individuals, the results showed considerable increase in the white blood cell counts especially neutrophils and monocytes. These results were correlated with previous reports where similar observations were made. Furthermore, from the analysis of liver and kidney function test, it was concluded that these vital organs were working with lowered efficacy. Conclusion: This study provides evidence that there is marked variation in the blood, hepatic, and renal parameters among individuals with OC as compared to healthy ones and hence has prognostic value.