Affiliation:
1. Department of Pathology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India
Abstract
ABSTRACT
Introduction:
Acute myeloid leukaemia (AML) is a tumour of hematopoietic progenitors caused by acquired oncogenic mutations that impede differentiation, leading to the accumulation of immature myeloid blasts in the marrow. Aberrant phenotype is a phenomenon in which lymphoid-associated and other myeloid lineage markers are expressed in myeloblasts or myeloid-associated markers are expressed in lymphoblasts.
Materials and Methods:
Diagnosed cases of AML were included in this study to study the aberrant expression using multiparametric flow cytometry.
Results:
Out of a sample size of 50, 30 cases expressed aberrant CD markers. Male: Female ratio was 0.76. Majority of cases belonged to the age group >60 years of age. CD 7 was overall the most common aberrant CD marker.
Conclusion:
Immunophenotyping has a significant role in diagnosis and predicting prognosis of hematopoietic malignancies in the absence of more advanced diagnostic tools like cytogenetics.
Reference13 articles.
1. Evalution of CD9 and CD56 antigens expression in adult acute myeloid leukemia;Al-Mudallal;Int J Adv Res,2017
2. Flowcytometric Immunophenotypic characterization of acute myeloid leukemia (AML) in Sudan;Osman;Int J Hematol Dis,2015
3. Aberrant phenotype in Iranian patients with acute myeloid leukemia;Jahedi;Adv Pharm Bull,2014
4. The frequency of aberrant lymphoid antigens expression in 202 Iraqi patients with de novo acute myeloid leukemia;Al-Anizi;Iraqi J Hematol,2017