Seroprevalent study of cytomegalovirus infection in the regions of Jharkhand

Abstract

ABSTRACT Background: The Human Cytomegalovirus (HCMV) is a type of beta herpesvirus widespread in all human populations. It is estimated that up to 80-100% of adults worldwide and most infections are harmless and can cause severe health complications in infants, like hearing loss and developmental issues. Still, immunocompromised individuals can experience serious complications from the virus. Unfortunately, there is limited information on the prevalence of this virus in our country, and no studies have been reported on the rate of CMV transmission yet. Objectives: This study aims to evaluate the levels of IgM antibodies against Cytomegalovirus (CMV) in East Singhbhum, West Singhbhum, and Seraikela Kharsawan using an ELISA test. Methods: An indirect ELISA test was performed to detect anti-CMV IgM and the period of study was from January’2021 to June’2023. Results: The examination tested 55 people for the TORCH profile of CMV parameters from regions of East Singhbhum, West Singhbhum, and Seraikela Kharsawan. Here, 17 people (30.09%) were IgM positive by ELISA. Conclusions: The serological data confirms that CMV is not being monitored and recognized in the general population, which limits our study between CMV infection, disease, and clinically diagnosed outcomes. This understanding is crucial for the healthcare and policy sectors. Thus, we recommend implementing a surveillance and mindfulness program for at least one-fourth of the population in Jharkhand and continuing to explore and develop effective vaccines to control CMV infections.