A study to assess the severity and risk of COVID-19 breakthrough infection in admitted SARS-CoV-2 vaccinated individual

Abstract

ABSTRACT Background: No vaccine is 100% effective in prevention of infection. The possibility of breakthrough infection of SARS-CoV-2 also cannot be ruled out. So, our study aimed to find out severity and risk of breakthrough infection and find association between epidemiological factors associated with it. Methodology: A retrospective cross-sectional study was conducted on 148 admitted SARS-CoV-2 vaccinated individual from May 2021 to January 2022 by universal sampling method. A data was collected in the form of socio-demographic, Covid vaccine, clinical details, and outcome of admitted patients. An appropriate statistical test was applied. Results: Out of the total 148 vaccinated individuals, 66 (44.59%) belongs to 30–59 years of age group and maximum, i.e. 95 (64.19%) were males. 64.86% patients were vaccinated with both doses and 98 (66.26%) individuals were mild cases. Only 8 (5.40%) cases were re-infected with Covid-19 infection. 70.27% individual were comorbid. Out of 148 vaccinated individuals, only 11 (7.43%) individuals were died and among those 7 (63.636%) were comorbid. Conclusion: Despite being vaccinated, small percentage of people are still getting infected, requires hospitalization, and die because of COVID-19. As far as pandemic continues, continuous genome sequencing and tracking of SARS-CoV-2 is essential and strategies regarding vaccination should be adjusted accordingly.