Role of fetal hemoglobin in the development and progression of retinopathy of prematurity in preterm infants

Author:

Prasad Nishi1,Dubey Aditi1,Kumar Kavita1,Shrivastava Jyotsna2

Affiliation:

1. Department of Ophthalmology, Gandhi Medical College, Bhopal, Madhya Pradesh, India

2. Department of Pediatrics, Gandhi Medical College, Bhopal, Madhya Pradesh, India

Abstract

Purpose: The objective of this study was to find the association between fetal hemoglobin (HbF) concentration and retinopathy of prematurity (ROP) in preterm infants. Methods: In this observational, prospective, longitudinal study, a total of 410 preterm infants with <36 gestational weeks and <2.5 kg birth weight, who were attending ROP clinic in a tertiary care hospital of central India for 1 year duration were included. Dilated fundus examination was done as per ROP screening guidelines, and ROP was staged as per international classification for retinopathy of prematurity (ICROP) classification, 2021. HbF (%) was measured with high-performance liquid chromatography, and data was analyzed statistically. The relationship between HbF (%) and ROP was evaluated. Those infants who had ROP were further divided into treatment-requiring and non–treatment-requiring groups and HbF was compared in these groups at the first visit and after 1-month follow-up period. The outcome of ROP was studied with HbF levels. Results: A total of 410 preterm infants were included, out of which 110 infants had ROP (26.8%). Infants with ROP had significantly lower percentage of HbF with gestational age groups and birth weight groups, compared to infants without ROP. Higher percentage of HbF was associated with a lower prevalence of ROP. Higher concentration of HbF was found in the ROP infants who regressed spontaneously without treatment and less concentration was found in those who progressed to a severe disease and those who required treatment. The predictive ability of HbF (%) was 0.976 for ROP. Conclusion: Low fraction of HbF was found to be significantly associated with the development and progression of ROP.

Publisher

Medknow

Subject

Ophthalmology

Reference19 articles.

1. Retinopathy of prematurity: Advances in the screening and treatment of retinopathy of prematurity using a single center approach;Berrocal;Am J Ophthalmol,2022

2. Retinopathy of prematurity: Incidence, risk factors and evaluation of screening criteria;Gebesce;Turkish J Med Sci,2016

3. Retinopathy of prematurity in India: Incidence, risk factors, outcome and the applicability of current screening criteria;Patel;Int J Contemp Pediatr,2019

4. Study of fetal hemoglobin with different gestational age and birth weight of the newborn;Roy;Int J Contemp Pediatr,2021

5. Global, regional and national estimates of levels of preterm birth in 2014: A systematic review and modelling analysis;Chawanpaiboon;Lancet Glob Heal,2019

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3