Cytomegalovirus-related Cystitis in a Patient with Membranous Glomerulonephritis Receiving Cyclophosphamide: A Case Study

Abstract

Hemorrhagic cystitis is a familiar complication of cyclophosphamide therapy in patients receiving high doses of intravenous cyclophosphamide, which is commonly used as part of a chemotherapeutic regimen and as an immunosuppressant for various malignancies and connective tissue diseases. Acrolein, an active and urotoxic metabolite of cyclophosphamide, is the leading cause of this hazardous complication. However, there are very few case reports indicating the role of pathogens such as BK virus, adenovirus, cytomegalovirus (CMV), Escherichia coli, Proteus mirabilis, Klebsiella, and Candida as the triggers for hemorrhagic cystitis, after short courses and oral use of cyclophosphamide therapy. Here, we report a case of CMV-related cystitis in a patient with membranous glomerulonephritis, who received conventional doses of oral cyclophosphamide for a short duration and presented with hematuria. Cystoscopy, along with a microscopic examination of the bladder mucosa, revealed mononuclear viral inclusions indicating CMV were observed. The patient responded to antiviral therapy.