Lower Intelligence Quotient and Larger Brain Volume in the Precuneus among Patients with Graves’ Disease-Reference-Cited by-同舟云学术

Lower Intelligence Quotient and Larger Brain Volume in the Precuneus among Patients with Graves’ Disease

Published:2023 Issue:4 Volume:37 Page:200-204
ISSN:1028-3684
Container-title:Taiwanese Journal of Psychiatry
language:en
Short-container-title:

Author:

Lai Kuan-Yu¹,Lin Shih-Hsien¹²,Tseng Huai-Hsuan¹²,Lee I Hui¹,Chen Po See¹²,Chen Kao Chin¹,Huang Shih-Ming³⁴⁵,Yang Yen Kuang¹²⁶

Affiliation:

1. Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Taiwan

2. Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan

3. Department of General Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan

4. Department of Surgery, Chang Bing Show Chwan Memorial Hospital, Lukang Township, Changhua, Taiwan

5. Asian International Thyroid Center, Chang Bing Show Chwan Memorial Hospital, Lukang Township, Changhua, Taiwan

6. Department of Psychiatry, Tainan Hospital, Ministry of Health and Welfare, Tainan, Taiwan

Abstract

Abstract Objectives: Neuropsychiatric symptoms are related to hyperthyroidism. Whether global cognitive function is impaired is unclear. In this study, we intended to investigate whether patients with Graves’ disease (GD) are characterized by a lower intelligence quotient (IQ) and gray matter volume loss. Methods: We enrolled 36 patients with GD and 36 healthy controls. Intelligence quotient and other cognitive functions, such as memory and attention, were assessed. Magnetic resonance imaging (MRI) study was used to measure the gray matter volume for those study participants. Results: Significantly lower IQ scores (p < 0.001) and poor memory function (p < 0.05) were found among the patients with GD. We also found that patients with GD had a nonsignificant larger gray matter volume in the precuneus compared with that in healthy controls. Conclusion: The deficits on global and complex cognitive testing among patients with GD should be noted. We speculate that the larger gray matter volume in the precuneus might be due to compensation.

Publisher

Medknow

Subject

Marketing,Organizational Behavior and Human Resource Management,Strategy and Management,Drug Discovery,Pharmaceutical Science,Pharmacology

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