Andrographolide Attenuates Noise-Induced Hearing Loss by Ameliorating Cochlear Inflammation-Reference-Cited by-同舟云学术

Andrographolide Attenuates Noise-Induced Hearing Loss by Ameliorating Cochlear Inflammation

Published:2024-04 Issue:2 Volume:10 Page:204-212
ISSN:2311-8571
Container-title:World Journal of Traditional Chinese Medicine
language:en
Short-container-title:

Author:

Li Meng-Hua¹²³,Wang Wan-Qi⁴,Zheng Li-Ting¹,Chen Meng-Bing⁵,Chu Yang⁴,Qiao Miao⁴,Zhang Zuo-Li⁴,Naveena Konduru¹,Pan Yong⁶,Zhang Yun-Shi⁶,Sun He⁴,Ma Xiao-Hui⁴,Shi Xi¹²⁷

Affiliation:

1. Artificial Auditory Laboratory of Jiangsu Province, Xuzhou Medical University, Xuzhou, China

2. Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou, China

3. Department of ENT, Beijing Friendship Hospital, Capital Medical University, Beijing, China

4. National Key Laboratory of Chinese Medicine Modernization, Tasly Academy, Tasly Pharmaceutical Group Co., Ltd., Tianjin, China

5. Endoscopy Center, Ankang People’s Hospital, Ankang, China

6. Department of Respiratory Medicine, Xuzhou Infectious Diseases Hospital, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China

7. Department of ENT, The People’s Hospital of Rongchang District, Chongqing, China

Abstract

Abstract Objective: This study aimed to explore andrographolide’s mechanism of action and its protective effect on noise-induced hearing loss (NIHL). Materials and Methods: A mice animal model for NIHL was established through exposure to broadband noise at 120 dB sound pressure level for 4 h. Transcriptomics analysis and pharmacodynamic experiments were carried out. Results: Andrographolide enters the inner ear and effectively prevents hearing damage following noise exposure in the mice model for permanent hearing loss. Moreover, treatment with andrographolide inhibited the excessive activation of inflammatory factors in the cochleae of noise-exposed mice. Conclusion: Andrographolide might be a promising candidate for auditory protective drug investigation.

Publisher

Medknow

Reference34 articles.

1. Oridonin employs interleukin 1 receptor type 2 to treat noise-induced hearing loss by blocking inner ear inflammation;Chen;Biochem Pharmacol,2023

2. Biological activity of selected natural and synthetic terpenoid lactones;Surowiak;Int J Mol Sci,2021

3. Andrographolide attenuates inflammatory response induced by LPS via activating Nrf2 signaling pathway in bovine endometrial epithelial cells;Fu;Res Vet Sci,2021

4. The role of glia in the peripheral and central auditory system following noise overexposure: Contribution of TNF-α and IL-1β to the pathogenesis of hearing loss;Fuentes-Santamaría;Front Neuroanat,2017

5. Inflammatory and immune responses in the cochlea: Potential therapeutic targets for sensorineural hearing loss;Fujioka;Front Pharmacol,2014